菲尔-巴兰 有机化学家

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Phil Baran
Organic Chemist | Class of 2013
Inventing efficient, scalable, and environmentally sound methods for recreating in the laboratory natural products with potential pharmaceutical applications.


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Title
Organic Chemist
Affiliation
Scripps Research Institute
Location
La Jolla, California
Age
36 at time of award
Area of Focus
Chemistry
Website
Baran Lab
Scripps Research Institute: Phil Baran
Social
Twitter: Baran Lab
Published September 25, 2013
ABOUT PHIL'S WORK
Phil Baran is an organic chemist recreating pharmacologically interesting compounds isolated from natural sources de novo in the laboratory through an experimental methodology known as “total synthesis.” In nature, complex molecules are synthesized in catalytic pathways that have evolved incrementally over millions of years, but many cannot be harvested in sufficient quantities to provide viable pharmaceutical solutions. Baran has invented new approaches to synthesizing natural products en masse, offering solutions for the cost and supply problems in drug development and creating alternative methods for obtaining industrial quantities of biologically active compounds with minimal environmental impact.

Working across a broad spectrum of chemistry—from indole alkaloids to terpenes—he has devised ingeniously concise routes to notoriously challenging target molecules that are of great utility for pharmaceutical applications spanning antibacterial, antiviral, and tumor-inhibiting activity. More recently, he developed an affordable, elegant method for synthesizing cortistatin A, an unusual, marine-derived steroidal alkaloid that has shown strong potential in treating conditions ranging from macular degeneration to cancer due to its antiangiogenesis properties.

Baran has also devised a scalable and more economical route to synthesis of ouabagenin, a steroid indicated for the treatment of congestive heart failure, enabling broader use of a treatment option whose production costs put it out of reach for most patients. Baran’s research is not only enhancing our ability to make fundamental structures for a broad range of medicines and materials, but is also strengthening the intellectual foundations of organic chemistry.

BIOGRAPHY
Phil Baran received a B.S. (1997) from New York University and a Ph.D. (2001) from Scripps Research Institute. He was a postdoctoral associate (2001–2003) at Harvard University before joining the faculty of Scripps Research Institute, where he is currently a professor in the Department of Chemistry. His scientific papers have appeared in Nature, Science, Angewandte Chemie, and the Journal of the American Chemical Society, among others.



菲尔-巴兰
有机化学家 | 2013级
发明高效、可扩展和无害环境的方法，在实验室中重新创造具有潜在制药用途的天然产品。


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标题
有机化学家
工作单位
斯克里普斯研究所
工作地点
加州拉霍亚
年龄
获奖时为36岁
重点领域
化学
网站
巴兰实验室
斯克里普斯研究所。菲尔-巴兰
社会
推特。巴兰实验室
发表于2013年9月25日
关于菲尔-巴兰的工作
菲尔-巴兰是一位有机化学家，他通过一种被称为 "全合成 "的实验方法，在实验室里重新创造从自然界中分离出来的具有药理学意义的化合物。在自然界中，复杂的分子是通过催化途径合成的，这些催化途径经过数百万年的逐步演变，但许多分子无法获得足够的数量以提供可行的药物解决方案。巴兰发明了大量合成天然产品的新方法，为药物开发中的成本和供应问题提供了解决方案，并创造了替代方法，以最小的环境影响获得工业数量的生物活性化合物。

他的工作涉及广泛的化学领域--从吲哚生物碱到萜类，他为众所周知的具有挑战性的目标分子设计了巧妙而简洁的路线，这些分子在制药方面的应用包括抗菌、抗病毒和抑制肿瘤的活性。最近，他开发了一种负担得起的、优雅的方法来合成皮质素A，这是一种不寻常的、源自海洋的类固醇生物碱，由于其抗血管生成的特性，在治疗从黄斑变性到癌症的各种疾病方面显示出强大的潜力。

巴兰还设计了一条可扩展的、更经济的合成乌拉巴宁的路线，乌拉巴宁是一种用于治疗充血性心力衰竭的类固醇，能够更广泛地使用这种治疗方案，因为其生产成本使大多数病人无法承受。巴兰的研究不仅提高了我们为广泛的药物和材料制造基本结构的能力，而且还加强了有机化学的知识基础。

个人简历
菲尔-巴兰在纽约大学获得学士学位（1997年），在斯克里普斯研究所获得博士学位（2001年）。在加入斯克里普斯研究所之前，他是哈佛大学的博士后助理（2001-2003），目前是该研究所化学系的教授。他的科学论文发表在《自然》、《科学》、《Angewandte Chemie》和《美国化学会杂志》等刊物上。