约瑟夫-德里西 分子生物学家

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Joseph DeRisi
Molecular Biologist | Class of 2004
Developing the means to measure thousands of genes simultaneously in an effort to decode the mysteries of cellular function.

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Title
Molecular Biologist
Affiliation
University of California, San Francisco
Location
San Francisco, California
Age
35 at time of award
Area of Focus
Microbiology, Virology, and Immunology, Genetics and Molecular Biology
Published September 28, 2004
ABOUT JOESPH'S WORK
Joseph DeRisi is a molecular biologist who develops and uses new technologies for exploring the complex, interdependent pathways regulating gene expression. He extends the impact of recent advances in DNA sequencing by examining not just the population of genes within a cell, but also their interactions that lead to complex behaviors. DeRisi uses glass slides, carefully prepared with spots of DNA, arranged by robotic devices in a microarray, to make hundreds and even thousands of measurements of individual gene expression from a single experimental sample. His studies on the most common type of malaria parasite have revealed an unusual pattern of synchronized gene activity. This observation suggests that the infectious agent may be particularly sensitive to drugs that disrupt the gene synchronization necessary to move into the next phase of its life cycle. DeRisi has also demonstrated the power of microarrays for rapid characterization of unknown viral strains; he and colleagues used this method to identify and characterize a novel coronavirus responsible for the outbreak of Severe Acute Respiratory Syndrome (SARS) in early 2003. By enhancing methods for bulk measurement of gene activity and applying this technology to questions of vital biological and medical interest, DeRisi demonstrates the vast potential for discoveries in molecular genetics to decode the mysteries of cellular function and to advance the diagnosis and treatment of disease.

BIOGRAPHY
Joseph DeRisi received a B.A. (1992) from the University of California, Santa Cruz, and a Ph.D. (1999) from Stanford University. He was a postdoctoral fellow (1999–2000) and an assistant professor (2000–2004) in the Department of Biochemistry and Biophysics at the University of California, San Francisco; in 2004, he was promoted to his current position as an associate professor. His research has been published in such academic journals as Science, Nature Medicine, Proceedings of the National Academy of Sciences USA, and PLoS Biology.



约瑟夫-德里西
分子生物学家｜2004级
开发出同时测量数千个基因的方法，以努力解开细胞功能的奥秘。

约瑟夫-德里西的肖像
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标题
分子生物学家
工作单位
加州大学旧金山分校
工作地点
旧金山，加利福尼亚
年龄
获奖时35岁
重点领域
微生物学、病毒学和免疫学, 遗传学和分子生物学
发表于2004年9月28日
关于乔斯夫的工作
Joseph DeRisi是一名分子生物学家，他开发并使用新技术来探索调节基因表达的复杂、相互依赖的途径。他不仅研究细胞内的基因群，而且还研究导致复杂行为的基因相互作用，从而扩大了DNA测序最新进展的影响。DeRisi使用玻璃幻灯片，精心准备的DNA斑点，通过机器人设备排列成一个微阵列，对单个实验样本的单个基因表达进行数百甚至数千次测量。他对最常见类型的疟疾寄生虫的研究发现了一种不寻常的同步基因活动模式。这一观察表明，这种传染性病原体可能对破坏进入其生命周期下一阶段所需的基因同步化的药物特别敏感。DeRisi还展示了微阵列在快速鉴定未知病毒株方面的威力；他和同事们用这种方法鉴定和描述了2003年初爆发的严重急性呼吸系统综合症（SARS）的一种新型冠状病毒。通过加强基因活性的批量测量方法，并将这一技术应用于重要的生物和医学问题上，德瑞西展示了分子遗传学的发现在破解细胞功能的奥秘和推动疾病的诊断和治疗方面的巨大潜力。

个人简历
约瑟夫-德里西在加州大学圣克鲁兹分校获得学士学位（1992年），并在斯坦福大学获得博士学位（1999年）。他曾是加州大学旧金山分校生物化学和生物物理系的博士后研究员（1999-2000年）和助理教授（2000-2004年）；2004年，他被提升到目前的副教授职位。他的研究发表在《科学》、《自然医学》、《美国国家科学院院刊》、《PLoS生物学》等学术期刊上。